Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion
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Na+-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion
To clarify the physiological role of Na(+)-D-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1(-/-) mice were generated and characterized phenotypically. After gavage of d-glucose, small intestinal glucose absorption across the brush-border membrane (BBM) via SGLT1 and GLUT2 were analyzed. Glucose-induced secretion of insulinotropic hormone (GIP) and glucagon-like peptide 1 (GLP-...
متن کاملResponse to Comment on: Gorboulev et al. Na+-d-glucose Cotransporter SGLT1 Is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion. Diabetes 2012;61:187–196
The elegant paper from Koepsell and colleagues (1) demonstrates the apical GLUT2 mechanism, but appears at first sight to question its significance. However, when set in a physiological context, the results are those expected from the three roles of SGLT1 and the differences between fed rat and starved mouse. SGLT1 acts as 1) a transporter and 2) a powerful scavenger. In 2000, my laboratory pro...
متن کاملDietary regulation of the intestinal sodium-dependent glucose cotransporter (SGLT1).
Dietary regulation of the intestinal sodium-dependent glucose cotransporter (SGLT I ) Soraya P. Shirazi-Beechey*$, Susan M. Gribble*, I: Stuart Wood*, Patrick S. Tarpey*, R. Brian Beechey*, Jane Dyer*, Dennis Scottt and Patrick J. Barker$ *Epithelial Function and Development Group, Institute of Biological Sciences, University of Wales, Aberystwyth, Dyfed, SY23 3DD, U.K., +Division of Biochemist...
متن کاملMolecular events involved in glucose-induced intestinal Na+/D-glucose co-transporter (SGLT1) expression.
Kamohara, S., Ishii, K., Okada, T., Ui, M. and Ebina, Y. (1993) Biochem. Biophys. Res. Commun. 195,762-768 12 Okada, T., Kawano, Y., Sakakibara, T., Hazeki, 0. and Ui, M. (1994) J. Biol. Chem. 269, 3568-3573 13 Clarke, J. F., Young, P. W., Yonezawa, K., Kasuga, M. and Holman, G. D. (1994) Biochem. J. 300, 63 1-635 14 Yang, J., Clarke, J. F., Ester, C. J., Young, P. W., Kasuga, M. and Holman, G....
متن کاملRevised immunolocalization of the Na+-D-glucose cotransporter SGLT1 in rat organs with an improved antibody.
Previously, we characterized localization of Na(+)-glucose cotransporter SGLT1 (Slc5a1) in the rat kidney using a polyclonal antibody against the synthetic COOH-terminal peptide of the rat protein (Sabolić I, Skarica M, Gorboulev V, Ljubojević M, Balen D, Herak-Kramberger CM, Koepsell H. Am J Physiol Renal Physiol 290: 913-926, 2006). However, the antibody gave some false-positive reactions in ...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2011
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db11-1029